Treatment for Hep C


New generation direct-acting antiviral medications are available to Australians living with chronic hepatitis C. They are more effective, easier to take and have fewer side-effects than the older medications. The Australian Government has listed these new medicines on the Pharmaceutical Benefits Scheme (PBS), ensuring they are accessible and affordable to people with hepatitis C.  This is a leap forward in the management and treatment of hepatitis C and positions Australia as a world leader in publicly-funded access to these new, highly effective medicines.

What are the new medicines?
Direct-acting antiviral (DAA) medicines available on the PBS from 1 January 2017 include:

  • Daklinza® (daclatasvir)
  • Harvoni® (sofosbuvir + ledipasvir)
  • Ibavyr® (ribavirin)
  • Sovaldi® (sofosbuvir)
  • Viekira Pak® (paritaprevir + ritonavir + ombitasvir + dasabuvir) 
  • Viekira Pak RBV® (paritaprevir + ritonavir + ombitasvir + dasabuvir + ribavirin)
  • Zepatier®  (grazoprevir + elbasvir)

Following a clinical assessment, these medicines are used independently or in combination with other medicines depending on the person’s particular situation. For most people, this will mean treatment without the need to use interferon

Are the new medicines better than the previous ones?

Yes, the DAA medicines are:

  • more effective, resulting in a cure for 90-95% of people
  • taken as tablets only with very few side-effects
  • taken for as little as 8-12 weeks in most cases,
  • interferon-free for most people

Are the new medicines available for all people with Hepatitis C? 
Yes, the DAA medicines are available through the PBS for all people living with hepatitis C over the age of 18 and who have a Medicare Card. However, the particular combination of medicines used will depend on a range of individual factors including genotype, prior treatment experience and whether or not you have developed cirrhosis (liver scarring).

What about people who currently inject drugs? 
There are no restrictions applied to people who inject drugs as they are a priority population for hepatitis C treatment.  Whether or not a person currently injects drugs should not be used as criteria for restricting access to the new medicines.

Can people in prison access the new medicines?
Yes, people in prison are a priority population for hepatitis C treatment. The Australian Government has ensured the new medicines will be funded for people in prison.

Are there interferon-free options available for all genotypes?

Currently, interferon-free treatment options are available for genotypes 1, 2, 3 and 4. For now, treatment for people with genotypes 5 and 6 will still require taking a combination of one of the new medicines in conjunction with pegylated interferon and ribavirin, but for a shorter duration than before. Other new DAA medicines in development are likely to be considered by the Australian Government for listing on the PBS. Also, as new data becomes available the use of current medicines may be broadened to include other genotypes. Hepatitis Australia will provide further information about interferon-free options for genotypes 4, 5 and 6 as it becomes available. 

What information will the doctor need to know about your health before treatment can be prescribed?

The doctor will do a number of tests and request certain information from you before treatment can be prescribed. These include:

•    undergoing blood tests to confirm you have active hepatitis C infection
•    undergoing tests to determine the genotype (strain) of hepatitis C you have
•    undergoing an assessment to see if you have developed cirrhosis (liver scarring)
•    discussing any previous treatments for hepatitis C you may have had
•    identifying any other illnesses or health complaints you have, and;
•    discussing any other prescription medicines, over-the-counter medicines, or other substances you are taking. This is important to avoid any possible drug interactions

It is very important that medicines are taken as instructed, so the doctor or nurse may also talk with you about your readiness to start treatment and discuss things that may impact on your ability to take the medicine regularly and as prescribed..

What does treatment with the new medicines involve? 

The treatment regimens for the new DAA medicines range between 8 and 24 weeks for a complete course of treatment. This will depend on your genotype, treatment history, whether you have cirrhosis and the combination of medicines used.  (Refer to the table at the end) Some treatments require only 1 to 2 tablets once or twice a day. For some treatment regimens, more than one medicines may be required. Depending on treatment history and genotype, some people may still need injections (of peg-interferon) as well as taking tablets. Your doctor will explain the options available to you in more detail.

Will you need to have more tests during treatment?
Yes, the doctor will need you to have blood tests to monitor how your body is responding to the medicines. This means checking if the medicine is working effectively against the hepatitis C virus and that it is not negatively affecting your overall health.

Can General Practitioners (GPs) prescribe treatment for hepatitis C?
Yes, GPs in Australia can prescribe the new medicines.  Before prescribing any medicines, your GP will collect information and conduct tests (see above) to establish which combination of medicines will be the most effective for you. The GP may then consult with a specialist before prescribing the medicine for you. This means it is likely you will need a couple of appointments before receiving a prescription. In some cases, where there are other significant health factors to consider, the GP may refer you to a specialist before treatment is commenced.

Can you still see your specialist to access the new medicines?
Yes, gastroenterologists, hepatologists or infectious diseases physicians, experienced in the treatment of chronic hepatitis C, will continue to prescribe the new medicines. These specialists can also provide advice to GPs prescribing the new medicines, so you may consider seeing your GP if this is more convenient. 

Where can you get your prescription filled?

This will depend on the type of prescription you receive and the doctor will provide more details. There are two types of prescriptions known as either s100 or s85.

Most people will receive the s85 prescription, which can usually be filled by your local pharmacy. However, it is important to note that some pharmacies may not have the medicines in stock and you may need to wait up to 72hrs to collect them.  This is due to the very high cost the pharmacies have to outlay to keep the medicines in stock.  If a pharmacy cannot fill your prescription, ask them for a referral to a pharmacy that can, or contact a local
hepatitis organisation for assistance.

Some people accessing specialists may receive an s100 prescription. These can only be filled through hospital-based pharmacies and not local, community-based pharmacies. Some prescriptions may only allow you to collect a 4 week supply of medicine at a time. So it is important to plan ahead so you don’t run out of medicine.

How much do the medicines cost you? 
You will be charged the usual co-payment price you pay for the dispensing fee of each prescription. This is currently $38.30 for general patients and $6.20 for concessional patients. This fee is reviewed each year.

Remember, as these medicines are PBS ‘Authority required’ the doctor can only prescribe one medicine on each prescription. This means you may be required to pay the dispensing fee for each medicine.

What if treatment is not effective for you?
For most people it is highly likely the new DAA medicine will be effective. If the new treatment does not work for you, your doctor will refer you to a specialist for further assessment prior to commencing any further treatment.

Where can you get further information?
You can talk to your GP, specialist, clinic nurse or call the
National Hepatitis Information line on 1800 437 222.

Treatment options available on the PBS since 1 May 2016
The treatment options below are based on the ‘Australian recommendations for the management of hepatitis C virus infection: a consensus statement 2016’. You can view this at

Some variations to these regimens may be required depending on a person’s individual clinical history or health status and Interferon containing regimens are only shown where there are no other PBS option is currently approved. For more detailed information you can discuss options with your doctor.

Don’t put your health at risk by waiting too long.

It’s easy to understand why you might have waited for the new interferon-free treatments to become available. However, now treatment is much simpler and by waiting, you could be putting your health at risk.

If you’re 40 years of age or over, you’re likely to experience an accelerated rate of liver damage which increases your risk of developing cirrhosis, liver cancer or liver failure. This is called the ‘Liver Danger Zone’.

You should also bear in mind that symptoms of liver disease may not be felt until the liver is significantly scarred.

Please don’t put your health at risk by waiting too long for treatment. Make an appointment with your doctor to have a liver health assessment and treatment discussion with your doctor at least once a year.

What does a liver health assessment involve?

Your doctor will give you a clinical examination and blood tests. They may also use a Fibroscan® – a quick, non-invasive test (similar to an ultrasound) that measures the level of liver scarring to determine the severity of liver disease.

For further information on the liver health assessments see our:

Liver Assessment Factsheet - download now (PDF 184kb)
Video of a liver health assessment - view now

If you have chronic hepatitis C and particularly if you are in the ‘Liver Danger Zone’, ask your doctor about having a regular liver health check-up today. A liver check-up is nothing to worry about, it is simple, easy and it could save your life..